Nalloxan induced diabetes in rabbits pdf free download

This article is from bmc veterinary research, volume 10. Development and characterization of an experimental model. Pathomorphological effects of alloxan induced acute. Pdf diabetes is a chronic metabolic syndrome that affecting million of people around the world. These are some of the earliest known organic compounds. The first group 5 rabbits was used as control and fed with standard chow and tap water. It is a dreadful disease found in all parts of the world and is becoming a serious threat to mankind health.

The antianginal agent ranolazine lowered hba1c levels when given as monotherapy, or with a sulfonylurea, in patients with type 2 diabetes. From there, you can view and download your ashp ebooks to the reader of your choice. T1 rabbit model of chest wall rigidity induced by fentanyl and the effects of apomorphine. Efavirenz and nevirapine are widely used nonnucleoside reverse transcriptase inhibitors for the treatment of hiv infection. Efficacy of protamine zinc insulin for treatment of. Autoxidation of dialuric acid generates superoxide radicals. Diabetes materialien zum download diabetesinformationsdienst.

Diabetes mellitus induced persistent hyperglycemia causes increased production of free radicals especially reactive oxygen species as superoxide that generated by the process of nonenzymatic. Bone regeneration in cranioplasty and clinical complications. Fresh liver weight and its relationship with body weight were obtained, and liver. In diabetes, hyperglycemia generates reactive oxygen species ros, which in turn cause lipid peroxidation and membrane damage and these free radicals play an important role in the production of secondary complications in diabetes mellitus kidney, eye, blood vessel, and nerve damage 4. Jan 01, 2001 procedure34 cats with newly diagnosed diabetes and 33 cats with poorly controlled diabetes were treated with pzi twice daily for 45 days. Bumetanide, furosemide, and torsemide may cause hyperglycemia and glycosuria in patients with diabetes mellitus, probably due to diuretic induced hypokalemia. U department of pharmacology, college of health sciences, usmanu danfodiyo university. The book discusses the druginduced pathobiotic effects. Induced bullous dermatosis in a patient with respiratory failure.

Intramuscular or intraperitoneal injection of a single alloxan dose 300 mgkg is shown to cause a temporary, modest rise in blood glucose levels in the chinese. Diabetes mellitus is a common and serious metabolic disorder throughout the world. At least 72 hours after alx injection, fasting blood glucose from 8. Carbamazepine potentiates the effectiveness of morphine in. Time courses of concentrations of 3hfentanyl in plasma and several organs and tissues after i. Control of glycemia was assessed on days 7, 14, 30, and 45 by evaluation of clinical response, change in body weight, serum fructosamine concentration, blood glucose concentration measured 1, 3, 5, 7, and. Dec 18, 2007 alloxan and streptozotocin are toxic glucose analogues that preferentially accumulate in pancreatic beta cells via the glut2 glucose transporter. Experimental models play an important role in understanding such a disease, which is treatable only. Research article alloxan induced diabetes mellitus in. This study describes a rat diabetes mellitus model induced by administering a reduced dose of alloxan, thus greatly reducing the animals death rate. Isoproterenolinduced ultrastructural alterations in hearts. Oxidative stress in kidney and liver of alloxaninduced. The effect of aepe leaf extract on blood glucose, insulin, hemoglobin and. Ivermectin can simultaneously tackle these issues by killing mosquitoes feeding on treated animals and humans.

Mechanisms of drug toxicity, volume 4 presents the proceedings of the 3rd international pharmacological meeting held in sao paulo, brazil in 1966. Histopathological abnormalities of prolonged alloxaninduced. The pathobiologic mechanism of angioedema with regard to ace inhibitor therapy is believed to relate to the kallikreinkinin plasma effector system. Alloxan induced diabetic rabbits as animal model for. The role of efavirenz and nevirapine on the pharmacodynamic activity of gliclazide is not currently known. Since the first edition of this book was published in 2005, numerous drugs have been withdrawn from the market in the united states as a result of morbidity andor mortality associated with drug induced diseases. Diabetes mellitus is the most important non infective epidemic to hit the globe in the present millennium. Induced bullous dermatosis in a patient with respiratory failure mr ming. Differential effect of honey on selected variables in. Diabetes mellitus is a group of metabolic diseases characterized by high blood sugar levels that result from defects in insulin secretion, or action, or both. Experil1lelllal design the pharmacokinetic evaluation of carbamazepine was done on.

Effect of alloxan time administerdrug on establishing. Alloxan exerts its diabetogenic action when it is administered parenterally. Szkudelski department of animal physiology and biochemistry, university of agriculture, poznan, poland received november 2, 2000 accepted march 20, 2001 summary alloxan and streptozotocin are widely used to induce experimental diabetes in animals. Carbamazepine potentiates the effectiveness of morphine in a. Metabolomic analysis of fatty acids and related compounds. The aim of this study was to analyse the effect of the new oral antidiabetic drug repaglinide on antioxidant factors and lipid peroxidation in tissues of alloxaninduced diabetic rabbits after 4 and 8 weeks treatment. Animals models for studying diabetes mellitus etuk, e. Another 12 agematched normal rabbits were used as controls. Diabetes mellitus is a potentially morbid condition with high prevalence worldwide, thus being a major medical concern. Bumetanide, furosemide, and torsemide may cause hyperglycemia and glycosuria in patients with diabetes mellitus, probably due to diureticinduced hypokalemia.

Comprehensive notes on anti diabetic potential of medicinal. It has been successfully induced in a variety of animal species. Miller medical 2010 1110 according to the authors, a druginduced disease as an unintended effect of a drug, which results in mortality or morbidity with symptoms sufficient to prompt a patient to seek medical attention andor require. Despite best efforts to assure that all drugs are safe and effective, millions of patients each year develop druginduced diseases. The bioavailability and pharmacokinetics of mefenamic acid was studied in alloxan diabetic rabbits. Three different slowrelease formulations of ivermectin were. Study was carried out on alloxan induced diabetic rabbits. The mechanism of alloxan and streptozotocin action in b cells. Data were fourier transformed after the free induction decay. The time course of concentration in plasma could be divided into three phases. This study evaluated the longterm effects of alloxan induced diabetes in rat liver. With this agent, it is possible to produce different grades of severity of the disease by varying the dose of alloxan used. Pge 1 removal by eliminating surface area changes associated with endotoxin.

The best known druginduced diabetes model is the alloxan diabetes. Alloxan monohydrate is used to induce diabetes mellitus in albino rats in the dose of 120mgkg i. Despite best efforts to assure that all drugs are safe and effective, millions of patients each year develop drug induced diseases. Since the first edition of this book was published in 2005, numerous drugs have been withdrawn from the market in the united states as a result of morbidity andor mortality associated with druginduced diseases. There was a similar inhibition of the deposit of lipid substances in the liver, spleen, and adrenal glands of the diabetic rabbits. In the second set of experiments, endotoxemia was induced with lps dissolved in 0. The aim of this study was to analyse the effect of the new oral antidiabetic drug repaglinide on antioxidant factors and lipid peroxidation in tissues of alloxan induced diabetic rabbits after 4 and 8 weeks treatment. In the case of control of lymphatic filariasis in africa, it is used in combination with donated albendazole. Download limit exceeded you have exceeded your daily download allowance. The alloxan model of diabetes was first described in rabbits by dunn, sheehan and mcletchie in 1943. Alloxaninduced diabetes, a common model for evaluating. Changes in blood glucose f profile of alloxaninduced diabetic rabbits for 26. In the presence of intracellular thiols, especially glutathione, alloxan generates reactive oxygen species ros in a cyclic redox reaction with its reduction product, dialuric acid.

The name is derived from allantoin, a product of uric acid excreted by the fetus into the allantois, and oxaluric acid derived from oxalic acid and urea, found in urine. Alloxan, sometimes referred to as alloxan hydrate, refers to the organic compound with the formula ocnhco 2 coh 2. The anhydrous derivative ocnhco 2 co is also known as well as a dimeric derivative. A case of gabapentininduced angioedema shm abstracts. Alloxan induced diabetes is a form of insulindependent diabetes mellitus that occurs as a result of alloxan administration or injection to animals. Isoproterenolinduced ultrastructural alterations in. The effects of isoproterenol iso on the ultrastructure of hearts from 10week alloxan diabetic rabbits were examined. This study was to create a longterm rabbit model of diabetes mellitus for medical studies of up to one year or longer and to evaluate the effects of chronic hyperglycemia on damage of major organs. Alloxan, a pyrimidine nucleic acid, has a cytotoxic effect on cells and has been used to induce diabetes in the chinese hamster.

Opioid overdose in dogs is manifested by clinical signs such as excessive sedation, bradycardia, and hypothermia. Chia lee ms department of pharmacy, buddhist tzu chi general hospital, taipei branch, taiwan. This study evaluated the longterm effects of alloxaninduced diabetes in rat liver. Sir, we read with interest the article titled anomalies in alloxan induced diabetic model. Thirty nondiabetic control rats nc and 30 untreated diabetic ud rats were divided into three subgroups sacrificed after 6, 14, or 26 weeks. Briefly, one hour before surgery, rabbits were injected subcutaneously with buprenorphine. Alloxan and streptozotocin are toxic glucose analogues that preferentially accumulate in pancreatic beta cells via the glut2 glucose transporter. Altered glucose metabolism and hypoxic response in alloxan. Angioedema, gabapentin and internal medicine, intensive care unit. Systemic and antinociceptive effects of prolonged lidocaine.

Free access to water and standard pellet diet was provided to all rabbits. In untreated animals, endotoxin transiently decreased pulmonary removal of 3 h. Analgesic efficacy and respiratory effects of butorphanol. Hospital medicine 2016, march 69, san diego, calif. Pdf the bioavailability and pharmacokinetics of mefenamic. Influence of nonnucleoside reverse transcriptase inhibitors. Currently available therapies for diabetes include insulin. By the year 2025, india shall have the maximum number of diabetes in the world making it, the diabetes capital of the world.

Gliclazide is a widely used drug for the treatment of type 2 diabetes. We compared the effects of endotoxin on pulmonary prostaglandin e 1 pge 1 removal in groups of rabbits pretreated with the cyclo. Opiate receptors may be involved in some of the effects produced by morphine injection in the human skin, but morphine. If blood glucose could more than triple the base value for 2 continuous weeks and remained stable, the. Butorphanol tartrate page 2 of 3 drugs for rabbits in case this drug is administered concurrently with other cns depressants alcohol, analgesic agents, antihistamines, barbiturates, phenothiazine tranquilizers, the dosage of butorphanol needs to be reconsidered and may. In remaining ten rabbits, diabetes mellitus was induced by alloxan monohydrate 150 mgkg by intraperitoneal administration.

It is better to standardize it first by jain et al. Alloxan was injected into the rats through a tail artery and three days later, a confirmation of successful induction of diabetes was made by demonstration of hyperglycemia in the rats. Efficacy of protamine zinc insulin for treatment of diabetes. We conclude that indomethacin acts to prevent the depression of pulmonary 3 h. Differential effect of honey on selected variables in alloxan. The mechanisms of alloxan and streptozotocininduced diabetes. Research article alloxan induced diabetes mellitus in wistar. Effect of honey on carbamazepine kinetics in rabbits. They also exhibit a variety of biological activities. Objectiveto test the hypothesis that butorphanol or morphine induces antinociception with minimal respiratory depression in conscious redeared slider turtles designprospective crossover study animals37 adult male and female redeared slider turtles trachemys scripta proceduresantinociception n 27 turtles and respiratory 10 turtles experiments were performed. Type 2 diabetes may occur as a result of hiv infection andor its treatment. Diabetes mellitus was induced in the rabbits by a single 90 mgkg intravenous injection of the pancreatic bcells toxin monohydrate alloxan sigma aldrich chemical saint louis, mo, usa.

Ashp ebooks sign in with your ashp username and password to access purchased ebooks in my library. A simple method for measuring 3hfentanyl concentration in plasma separated from its radioactive metabolites is described. The name is derived from allantoin, a product of uric acid. Antihyperglycemic effect of green tea in alloxan induced diabetic. Prolonged drug infusions are used to treat horses with severe signs of pain, but. Objectiveto evaluate effects of protamine zinc insulin pzi on control of glycemia in cats with newly diagnosed diabetes mellitus or poorly controlled diabetes designclinical trial animals67 diabetic cats procedure34 cats with newly diagnosed diabetes and 33 cats with poorly controlled diabetes were treated with pzi twice daily for 45 days. The time course of concentration in plasma could be divided into three. Alloxan has been administered in single or multiple doses, through different routes intraperitoneal. Mefenamic acid in plasma was assayed by high performance liquid chromatography. Effects of lowdose escherichia coli lipopolysaccharide.

The mechanism of alloxan and streptozotocin action in b cells of the rat pancreas t. Morphine ed 50 values for the low dose range effect rose from 0. View the article pdf and any associated supplements and figures for a period of 48 hours. Unlimited viewing of the articlechapter pdf and any associated supplements and figures. Abstractapproximately 60% of morphine is glucuronidated to morphine3glucuronide m3g which may aggravate preexisting. Krayton gilbert blower, do and daniel levin, md, university of texas health science center san antonio, san antonio, tx. Diabetic atherosclerosis was induced in rabbit iliofemoral arteries by. We used alloxan to induce diabetes in rats and rabbits for screening the antidiabetic activity of test compounds. Rabbits are increasingly being used as experimental diabetic models and alloxan has been the chemical of choice for the development of rabbit models of diabetes. Pdf effect of trigonella foenum methi on fasting blood glucose. Rabbit model of chest wall rigidity induced by fentanyl. Since then, alloxan diabetes has been commonly utilized as an animal model of insulindependent diabetes mellitus iddm.

Alloxan induced diabetic rabbits as animal model for diabetes. The prospect of eliminating malaria is challenged by emerging insecticide resistance and vectors with outdoor andor crepuscular activity. These agents selectively destroy the langerhans islet. Fixed drug eruption induced by lidocaine kawada 2006. Waterretaining fibers, especially the mucilaginous. To explore the effect of alloxan time administerdrug on establishing diabetic rabbit model. The mechanism of alloxan and streptozotocin action in b. Before administration, fasting blood glucose of all rabbits was measured for three times from 8.

In animals, it can be induced by partial pancreatectomy or by the administration of diabetogenic drugs such as alloxan, streptozotocin, ditizona and antiinsulin serum. A single oral dose, however, confers only shortlived mosquitocidal plasma levels. Experimental model of induction of diabetes mellitus in rats. Because of this, a potential pharmacodynamic interaction exists between these drugs and all antidiabetic agents. Fresh liver weight and its relationship with body weight were obtained, and liver tissue was. A single dose of alloxan monohydrate 100 mgkg was given intravenously to 20 young new zealand white rabbits. In areas coendemic for onchocerciasis and loa loa, serious adverse reactions have been observed. The bioavailability and pharmacokinetics of mefenamic acid was studied in alloxandiabetic rabbits. Feeney, in the laboratory rabbit, guinea pig, hamster, and other rodents, 2012. To evaluate the effect of longterm diabetes on wound healing, we created full thickness skin wounds on the ventral surface of the pinnae in both diabetic and nondiabetic agematched rabbit groups at 2 weeks and one year using a minimally invasive surgical technique 9, 10.